Sickle Cell Anemia

1st Hr
10/13

10/14

10/15

10/16

10/19

10/20


10/21

10/22

10/23

10/26

10/27


10/28

10/29

10/30

11/2

11/3

11/4
4th Hr.

1/5

1/7

1/11

1/13

1/15

1/20


1/22

1/26

1/28

2/1

2/3


2/5

2/9

2/11

2/17

2/19

2/23
Day:

1

2

3

4

5

6


7

8

9

10

11


12

13

14

15

16

17
; Lesson:

Blood Detectives 3.1.1

Sickle Cell Diaries 3.1.2

Protein Synthesis 3.2.1;

The Genetic Code; "Cracking Your Genetic Code" 3.2.2

What is the DNA Code? (Bioinformatics map) 3.2.2.5; Gene regulation discussion

Use water kits for hydro phobic/philic; Does Changing One Nucleotide Make a Big Difference? 3.2.3

DNA to Protein - Sickle Cell Disease; Designer Proteins

3.1 - 3.2 Quiz; (HeLa video intro) 

The Immortal Cells 3.3.3 - part 1

Chromosomes: A Closer Look 3.3.2 set-up (video); 3.3.3 part II debate

3.3.2 - Part 1 - cell observation and chromosome spread counts; karyotype - patient diagnoses

How is DNA Passed Through the Generations? 3.3.1

Family Inheritance 3.4.1

What's the Probability? 3.4.2 - Allele Frequencies and Sickle Cell Anemia 

World Distribution of Sickle Cell Disease 3.4.3

Portfolio work Unit 3 Review

Unit 3 Test



 
STANDARDS:

Indicator #3: Sickle Cell Disease: DNA structure; protein synthesis; genetics; HIPAA

Webb’s Leveling Standard and Examples
  • Recall - PBS 3.1 Use appropriate Internet research techniques to obtain information on the relationship between sickle cell carriers and malaria resistance.
  • Recall - PBS 3.2 Explore the process of protein synthesis through various interactive tutorials.
  • Skill/Concept - PBS 3.3 Use proper microscope technique to examine and record observations of normal and sickle red blood cells
  • Skill/Concept - PBS 3.4 Complete a hematocrit in order to determine if a patient has anemia.
  • Skill/Concept - PBS 3.5 Fill in a concept map outlining the process of protein synthesis.
  • Skill/Concept - PBS 3.6 Calculate the probability of a trait appearing in offspring.
  • Skill/Concept - PBS 3.7 Use proper laboratory techniques to create and analyze a chromosome spread of human HeLa cells.
  • Skill/Concept - PBS 3.8 Research HIPAA laws and discuss whether HIPAA was broken or not in various scenarios.
  • Strategic Thinking - PBS 3.9 Apply knowledge of protein synthesis in order to decode a secret message.
  • Strategic Thinking - PBS 3.10 Use computer-modeling software to investigate the effects that various mutations have on protein production, specifically the sickle cell mutation.
  • Strategic Thinking - PBS 3.11 Create and analyze pedigree charts to illustrate passage of a trait through at least three generations.
  • Strategic Thinking - PBS 3.12 Research the history of HeLa cells and discuss the ethics surrounding the commodification of human body parts.
  • Strategic Thinking - PBS 3.13 Analyze gel electrophoresis pictures to determine a patient’s genotype for sickle cell mutation.
  • Extended Thinking - PBS 3.14 Write diary entries detailing a sickle cell patient’s treatment options and evaluate the risks and benefits of these options.
  • Extended Thinking - PBS 3.15 Design a protein with a specific function by specifying the sequence of nucleotides in the protein’s gene.